Welcome To Microbiota Labs LLC
Our research interest is to understand the role played by the intestinal microbiota in health and disease, with a focus on inflammatory, autoimmune, and metabolic disorders.
Our goals are to
- elucidate the basic mechanisms that underlie the interaction between the microbiota and inflammatory, autoimmune, and metabolic disorders, and
- devise and implement strategies to prevent and treat such disorders via the microbiota.
We investigate the principles that govern microbiota community function and interaction with the host using experimental systems that include gnotobiotic and conventionally raised mice. We pursue molecular mechanisms of host-microbial interaction using an array of technologies including gnotobiotic and conventional mouse models, quantitative imaging, molecular genetics and synthetic biology, and metabolomics analysis focused on defining microbiota-dependent metabolites. The synergy of these diverse techniques provides insight into the dynamics of a microbial ecosystem in response to cues ranging from nutrition to pathogen-induced inflammation.